About Gina¹

Each film-coated vaginal tablet contains 10 micrograms of estradiol.

Low dose estradiol in the same form as Gina has been available on prescription for over 30 years.²

The tablet is in a pre-loaded applicator; it works directly where it is applied by adhering to the vaginal mucosa for gradual and controlled release of vaginal oestrogen. The oestrogen stays within the vagina and low levels are released into the bloodstream. Gina contains 10 micrograms of estradiol and if continually used for 1 year it delivers an oestrogen dose of 1.14 milligrams per year. This oestrogen dose is roughly equivalent to one tablet of oral HRT.³

There are different dosage schedules to follow (described later on in this module), depending on whether Gina is being used for the first time, after a treatment break, or continued use. Each pack contains 24 pre-loaded applicators. A first pack lasts for 7 weeks and the maintenance dose for 3 months.

Patients that have never previously used a local oestrogen therapy may not see an improvement that they consider significant until after 3 months of treatment; however, Gina can significantly relieve women’s most bothersome symptoms in 8-12 weeks, so they may notice improvements earlier.⁴ Patients should have a consultation to discuss ongoing treatment at every return visit to confirm it is still appropriate to use Gina.